When you receive a DM from someone on Instagram, there are a few things you can do in order to reply. The first thing you should do is open the DM and read it. If you don’t know who the person is or if you don’t want to respond, then just delete the message. If you do know who the person is, then follow their account and reply when they send a DM. If you don’t want to respond, then just delete the DM and forget about it.