It happened in the eastbound lanes near Winston Churchill Boulevard at the border of Mississauga and Oakville.
Police said they are still looking for the vehicle from which the tire came off.
OPP Sgt.  Kerry Schmidt spoke to CP24 from the scene and called the incident “tragic.”
“We have a male deceased who was involved in a collision with a runaway wheel from a vehicle that was traveling in the other direction,” Schmidt said.
Schmidt said the wheel struck the first vehicle where the deceased was located before bouncing off and hitting two other vehicles.
No other injuries have been reported at this time, but police are following up with witnesses to locate the vehicle, which police believe is missing a wheel.
The eastbound lanes of the QEW at Ford Drive are now closed as the incident is investigated, according to Halton Police.  The eastbound ramp from Ford Drive is also closed and police are asking drivers to consider alternate routes due to “significant traffic congestion” in the area.

	ROAD/RAMP CLOSURE:

The eastbound QEW is closed at Ford Drive due to an OPP investigation. The eastbound ramp to the QEW from Ford Drive is closed. Please use alternative routes or avoid the area as we expect significant traffic congestion as a result of the closure. pic.twitter.com/QaVba4V5ox — Halton Police (@HaltonPolice) October 18, 2022 The Department of Transportation has confirmed that one person is dead as a result of the incident, although it is unclear at this time whether it was the driver or passenger of the vehicle that was hit by the tire. This is breaking news. More to come.