According to the Ontario Provincial Police, the incident occurred near Highway 401 and Holt Road in Durham Region.
Investigators say six other people were taken to the hospital with non-life threatening injuries.
Fatal accident: Seven vehicle crash wb #Hwy401/Holt Rd. One man was pronounced dead – 64 from Pickering, 6 others were taken to hospital with non-life threatening injuries. The reopening is expected at 13:00. #TorontoOPP investigating #DriveSafe pic.twitter.com/9kfO2JaLjh
— OPP Safety Division (@OPP_HSD) November 1, 2022
Roads in the area are closed while police investigate the incident.
Investigators are warning of major congestion in both Bowmanville and Oshawa as a result. Roads are expected to reopen around 1 p.m