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Source/Disclosures Posted by: Disclosures: The authors report no relevant financial disclosures.
ADD SUBJECT TO EMAIL NOTIFICATIONS Receive an email when new articles are published Enter your email address to receive an email when new articles are published on . ” data-action=subscribe> Subscribe We were unable to process your request. Please try again later. If you continue to experience this problem, please contact [email protected] Back to Healio Pediatric patients with prior COVID-19 had a higher likelihood of a new diagnosis of type 1 diabetes compared with those with other respiratory infections, according to data published in JAMA Network Open. “The US Centers for Disease Control and Prevention reported that pediatric patients with COVID-19 were more likely to be diagnosed with diabetes after infection, although types 1 and 2 were not separated,” Ellen K. Kendall, a medical student at the Center for Artificial Intelligence in Drug Discovery at Case Western Reserve University School of Medicine, Cleveland and colleagues wrote. “Therefore, it remains unclear whether COVID-19 was associated with new-onset type 1 diabetes in the young.” Children have an increased risk of developing type 1 diabetes 1, 3, and 6 months after infection with COVID-19. Data are from Kendall EK, et al. JAMA Network Open. 2022; doi:10.1001/jamanetworkopen.2022.33014. The researchers obtained data from the TriNetX Analytics platform and identified two groups of children aged 18 years and younger: 314,917 with SARS-CoV-2 infection (mean age, 11.1 years, 49.9% girls) and 776,577 with non-SARS- CoV-2 respiratory infection and without SARS-CoV-2 infection (mean age, 7.2 years, 48.8% girls) between March 2020 and December 2021. The researchers matched these cohorts with 285,628 pediatric patients with COVID- 19 and 285,628 with non-COVID-19 respiratory infections. In the 6 months after COVID-19, 123 patients (0.043%) had a new diagnosis of type 1 diabetes and 72 patients (0.025%) were diagnosed with type 1 diabetes within 6 months after a respiratory infection without COVID-19. The risk for a diagnosis of type 1 diabetes was greater among patients with COVID-19 compared with patients with respiratory infections without COVID-19 at 1 month (HR = 1.96; 95% CI, 1.26-3.06); 3 months (HR = 2.1; 95% CI, 1.48-3) and 6 months (HR = 1.83; 95% CI, 1.36-2.44). Additionally, the researchers observed similar increased risks for fractures (HR = 2.09; 95% CI, 1.41-3.1) and well-child visits (HR = 2.1; 95% CI, 1.61-2 .73) among those with COVID-19 compared to other control cohorts at 6 months. “Respiratory infections have previously been associated with the onset of type 1 diabetes, but this risk was even higher among people with COVID-19 in our study, raising concern about long-term, autoimmune complications after COVID-19 in young people,” the researchers He wrote. “The increased risk of new-onset type 1 diabetes after COVID-19 adds an important consideration to the risk-benefit debates for prevention and treatment of SARS-CoV-2 infection in pediatric populations.”
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